Function of oral cavity

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Oral biofilms play an important role in the development of mucositis, caries and periodontal diseases. The salivary film, denoted pellicle, is formed by selective binding adsorption of proteins present in saliva. This film has many protective functions and thus promotes e. Due to the natural surface activity of proteins, adsorption usually takes place at almost any type of surface in contact with a biological fluid. It is well known that this initial layering monitors subsequent biofilm growth; thus the formation of the initial protein layer is an important clue in order to understand and control biofilm growth. Some of the known salivary pellicle key proteins are known to have multifunctional properties, e. Furthermore, some proteins are also known to play role in regulation of mineral homeostasis.

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Oral Mucosa in Health and Disease

Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis - a short report. T1 - Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis - a short report. N2 - Purpose: Recent reports indicate that histamine and its novel, high-affinity histamine H4 receptor H4R play a role in carcinogenesis, and thus H4R signalling has become a focus of increasing interest in the pathogenesis of many cancers. Quantitative real-time polymerase chain reaction was used to measure oncogene expression in the stimulated HOKs. Results: H4R-immunoreactivity was significantly reduced in OED and OTSCC samples, especially in the samples that had higher histopathological grades, which were also associated with noticeably increased mast cell counts.

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